The abstract is clear about the discoveries made by the study team and manages to adequately highlight the most important data such as that it was possible to isolate and identify two new compounds for the first time from a natural source. The title is quite general but includes the name of the specimen studied, so it will be easier for researchers to return to the study of the species Jatropha pelargoniifolia. The references used are quite extensive and it was possible to cite each of the procedures carried out in the methodology and many principles could also be extracted from previous studies of plants of the same family. This makes it possible to link this research to many previously carried out on plants of the same type, thus achieving that the paper is effectively positioned as an advance in the research of the Euphorbiaceae family.

The introduction briefly talks about the known properties of this plant and its anthropological background in the areas where it is distributed and the uses given by the humans who reside there, for both cases the pertinent citations can be found. For this study, there was not really a question, but there was a research topic which was made clear from the beginning, which consisted in evaluating the biologically active properties of some metabolite compounds produced by the plant. This research is justified in the ancestral use of this plant as a remedy to treat different diseases and infections and seeks to reveal which are the components present in it that are responsible for its medicinal properties

In the methodology of the experiment, the place from where the plant samples were extracted, the procedure for the extraction of its components, the materials used for the extraction, the chemical procedures used for the treatment of the sample and the analytical and chemical instruments are detailed. Then the anti-inflammatory, antinociceptive, antioxidant and antipyretic properties are also tested in mice which were obtained from the Experimental Animal Care Center, College of Pharmacy, KSU. The data is so detailed that the experiment is completely replicable.

The study presents a table with the results of the mass spectrograph for compounds 15 and 18, which are those that are isolated for the first time from a natural source. The structures of the 22 chemical compounds that were isolated from the roots of the plant are also presented. The data obtained from the procedure that tested the medicinal qualities of the compounds were presented only in the results and discussion section, but this information is not easily digestible for the reader as it makes it difficult to contrast the effects of the subjects who were treated with the root with those that were not, a comparative table for these results would allow a more detailed critical analysis and would facilitate the reading of this section of the paper.

The conclusions reaffirm that the objectives of the study were met and the possible utilities of the extracted compounds are discussed, as well as their properties to reduce pain and inflammatory conditions and how they could help in the treatment of other diseases. The design of this study was pertinent and allows to increase the knowledge of the properties of the plants of the Euphorbiaceae family and the results obtained justify the efficient use of this plant in traditional Saudi medicine as a remedy to cure various diseases and conditions.