Potential antiatherogenic mechanisms of ascorbate (vitamin C) and alpha-tocopherol (vitamin E) 10.1161/01.res.87.5.349 https://doi.org/10.1161/01.RES.87.5.349.

The aim of the study and the study results are very clear. The study title is informative and refers to the content of the article. In the study the references are relevant, recent, referenced correctly and including appropriate key study. The background is very informative about the topic. Also, the research question has been demonstrated and the research question has correctly specified the background. Also, the process of the subject is clear. The study methods (data collection) are valid and reliable. There are enough details to replicate the study. The data is presented suitably as figures are relevant and properly presented. The text in the result adds to the data and is not repetitive of the data. I am clear about what the statically significant results are and what the practically meaningful results are. The results are discussed from a different aspect, including mechanism and future outcomes. The conclusion answers the aims of the study and refers back to the research question it is also supported by results and references. There is a prospect to inform future research. The study is designed suitable to answer the aim. I have learned more information about the role of dietary in the atherosclerosis process that I didn’t know before. The major flaws of the article were that methods were not very clear and results did not support with graphs, tables or tissue culture images.

The Overall statement or summary of the article and its findings is the development and initiation of atherosclerotic plaque is a complex procedure relating numerous factors, counting oxidised LDL. This leading to develop atherosclerosis by different steps stating with endothelial dysfunction and macrophages derived foam cell formation. Dietary supplementation with a combination of two types of an antioxidant such as vitamin C and vitamin E, promising new therapeutic target for atherosclerosis, although vitamin E alone might be acting as a pro-oxidant rather than antioxidants. This explains why many clinical trials failed to treat cardiovascular disease with vitamin only. There are major points in the article which needs clarification, refinement, reanalysis, rewrites and/or additional information because :

1. Materials were not clearly explained
2. Methods were not clearly explained
3. There was no graphs or tables or images for tissue culture

Minor points like figures/tables not being mentioned in the text, a missing reference, typos, and other inconsistencies include; no graphs or tables or images for tissue culture, although its just review each result/paragraphs should refer to the graphs, tables and statistical analysis.