Content of review 1, reviewed on April 16, 2020

The present study claims to be the first multi-center large series analysis to evaluate the late-onset retinal findings and complications of ROP that did not require treatment during infancy.

Abstract: -the aim is clearly expressed -the study results are clearly summarized, the methodology is well documented -the title is informative and relevant -among 33 references cited most of them are recent and relevant

Introduction: -the topic is not very well covered yet, since there were only a few studies with a couple of children included that touched investigated retinal changes and other complications in eyes with insignificant ROP which didnt require treatment in infancy -the research question is clearly outlined

Methods: -this is retrospective, non-comparative, multi-center case series -inclusion criteria were well defined -instead of a simple demographics table, a flow chart of patients included in the study and also those excluded would give a clearer insight -the study is valid and reliable and offers enough methodological details to replicate it if needed

Results: -The results are mainly presented as percentage of the total -no real statistics is used to -different operations were used to repair retinal detachments and also this information is presented in percentages -other peripheral retinal changes (besides retinal detachments) are also documented and counted, it would be far more didactic if some diagrams were used instead of tables only

Discussion: -the discussion is overall quite extensive and well structured -is is well explained how the findings address the aim and emphasized how the findings fill the gap of knowledge, because there were no similar studies before -study limitations are collected in a special paragraph and are well addressed -take-home massage is clear and written in a separate paragraph

Overall, this is an important and well written paper which fills the knowledge gap in the field.

Source

    © 2020 the Reviewer.

References

    E., H. A., Omar, M., P., B. M., A., S. S., J., S. M., A., Q. P., A., M. D., M., B. A., Supalert, P., A., C. L., Shizuo, M., Yoshihiro, Y., Cindy, U., R., H. E., Ariitage, H. C., C., Y. R., G., B. C., Aaron, N., C., L. T., P., G. M., K., W. M., A., K. J., Peter, C. J., Andres, K., D., N. E., E., R. J., Ellzabeth, H. M., M., C. C., Y., C. E. 2020. Late-Onset Retinal Findings and Complications in Untreated Retinopathy of Prematurity. Ophthalmology Retina.