Content of review 1, reviewed on March 30, 2020
The authors of the manuscript “The Tumor Suppressor Effect of Ellagic Acid in SKOV-3 Ovarian Cancer Cells Entails Activation of Autophagy through Inhibition of mTORC1 Mediated by Activation of AMPK and Inhibition of Akt” aimed to investigate the effect of Ellagic acid on the proliferation, migration and invasiveness of ovarian cancer and the underlying mechanism.
- Overall, the manuscript needs language revision, there are some errors such as:
- Page 3, line 50; “this study is the first in literature the role of ….” Where is the verb in this sentence
- Page 6, line 8; study with then area exists???
- Page 9, line 5; both of which!
- Page 11, line 59 and page 12 line 3; these data are supported by other studies of other types…
- Page 12, line 46; “our data still very interesting” should be omitted.
- Page 3, line 36; Abbreviations should be mentioned full when mentioned for the first time.
- Page 13, line 26; (shown below), what is it meant by this sentence?
- Why the references for the methods used are not mentioned?
- The western blot figure and the corresponding magnitude of the bar chart do not in many figures e.g Figure 2, LC3; Figure 3, Bcl-2, p43/41. Results should be revised.
- Figure 8 C and D are very crowded
- Figure 8D; the numbers 1-5 stands for what?
Source
© 2020 the Reviewer.
Content of review 2, reviewed on May 05, 2020
Thank you for all changes in response to my comments
Source
© 2020 the Reviewer.
References
G., E. F., A., A. M., A., S. A., A., A. M., S., A. A., E., M. E., F., E. A., I, E. H., M., A. A., E., A. M. 2020. The anti-tumourigenic effect of ellagic acid in SKOV-3 ovarian cancer cells entails activation of autophagy mediated by inhibiting Akt and activating AMPK. Clinical and Experimental Pharmacology and Physiology.
