Content of review 1, reviewed on May 08, 2019
This paper is about the magnetic intraperitoneal drug delivery in a solid tumor. They investigated drug transport in macroscale. using domains for tumor, tissue, and the magnet. Overall, the postprocessing is appropriate to this study and the authors had the ability to extend the results and discussion. The abstract is appropriate to the whole article. The title is also in good agreement to the content.
In the Introduction section The author first fully described the treatment of cancer, especially peritoneal carcinomatosis. But I didn't see any distinction between the intraperitoneal drug delivery and intravascular drug delivery. The literature review is sufficient for this research, however, I didn't see any novelty in the geometry. It was just like the literature in the past decades, using a homogeneous circle for the tumor domain.
Comments on methodology
- how could you implement the magnetic force in comsol multiphysics? (more details is needed)
- you mentioned two different types of drugs which are Cisplatin and Paclitaxel but I can not see the diffences in the equations.
- in Eq.(12) you added the lymphatic term, but we know there is no lymphatic system in the solid tumor. so this term must be omitted.
- it is better to mention the open boundary condition rather than the seperate inflow and outflow term. 5.why do you assumed the solid tumor a simple circle?
Comments on data and results
- how did you measured the cisplatin and paclitaxel in figure 2?
- as you solved the time-dependent equation of mass transport, what is the exact time of your data in figures 3,4,5?
Comments on discussion and conclusions
the authors discussed their work which is previously worked by some other researchers. There is no data about the normal tissue and the geometry itself is not suitably showed. in the discussion section, I can not see that the writers refer to the limitations of their study.
Source
© 2019 the Reviewer.
References
Milad, S., Amir, S., Morteza, D., Mohsen, S., Mehdi, M., Amir, S. 2018. Magnetically assisted intraperitoneal drug delivery for cancer chemotherapy. Drug Delivery.
