The review conducted by Decourt brings the role of kisspeptin during early pregnancy, emphasizing how mouse models can provide valuable insights into the hormonal regulation of miscarriage, and their limitations. Despite interesting information, there are major points that should be revised:

1- The abstract should be revised: it does not bring solid and specific information concerning the review, just general information.

2 - Lines 122 to 127: please rewrite the phrases, because they are structurally very similar.

3 – Lines 148 and 149: RSA has already been defined.

1. Lines 193 and 194: Please clarify the role of Kiss-1 in the trophoblast proliferation, migration, and invasion, because it is unclear whether Kiss is beneficial or not for this. In addition, this topic is mentioned in the conclusion, and it must be clarified as well.

5- Line 207: “which act as natural inhibitors” - Please clarify this sentence.

6- Lines 207 and 208: “Kisspeptin treatment of mouse embryos to collagen I-coated culture dishes triggers”. Please specify what is collagen I-coated. What is the link between kiss and MMPs?

7 – Lines 211 and 212: Please, link this sentence with the others.

8 - Line 219: Please, remove the word “help”.

9 – Lines 232 to 234: Please clarify this difference between humans and mice, especially concerning mice.

10 – Lines 272 and 273: “a high serum E2 level makes the uterus refractory and impairs implantation in humans (55), and mice (56)”. By which mechanisms? would it be due to the contractile effect of E2 in myometrium? Please clarify.

11 – Lines 325 to 327: What are the pieces of evidence in other species, as in murines? does prolactin support corpus luteum function? Please clarify this information in the manuscript.

12 – Lines 342 to 344: This sentence refers to which species. Please clarify and
Specify it in the manuscript.

13 – Lines 369 to 371: Please clarify the role of this inhibition of trophoblast invasion and angiogenesis?

14 – Lines 401 to 402: Please clarify the role of kisspeptin in trophoblast migration, as previously asked.