Content of review 1, reviewed on December 12, 2024
Pyrrolo[1,2-α]quinoxalines are vital nitrogen-containing heterocyclic compounds with unique physical and chemical properties. In this work, Xie et al. describes a cascade radical addition strategy of 1-(2-isocyanophenyl)-1H-pyrrole via photocatalysis to afford 2-sulfenylpyrrolo[1,2-α]quinoxalines. This method is practicle. However, compared with previous strategies (Scheme 1 and 2), the substrate is complicated and expensive Ir catalyst is used.
Besides aryl disulfides, the authors should also try to see if diselenes are suitable for this reaction system, this is important.
More attractively, pyrazole, imidazole, indazole, and triazole should also be tested to see if they can be adapted to this cyclization system.
If the author can better solve the above problems, I agree to accept the article for publication.
Source
© 2024 the Reviewer.
Content of review 2, reviewed on March 21, 2025
I have read the revised manuscript carefully, and the authors have solved the problems raised by reviewers 1 and 2 well. I agree to accept the manuscript for publication in OBC.
Source
© 2025 the Reviewer.
References
Chen, C., Songzhi, K., Xiai, L., Minxia, W., Yazi, D., Xiaoke, L., Pinjin, Z., Haisheng, X. 2025. Visible-light-mediated synthesis of 2-sulfenylated pyrrolo[1,2-α]quinoxalines via isocyanide/disulfide radical cascades. Organic & Biomolecular Chemistry.
