Content of review 1, reviewed on September 04, 2024

The manuscript by Lauren S. et al. is interesting and well-described. The authors discuss pediatric odontogenic tumors in patients up to 20 years old and integrate a wide range of studies on odontogenic tumors in the pediatric population using a PRISMA-ScR chart, which represents methodological rigor. The manuscript details the number of articles selected. It focuses on pediatric and adolescent populations (<20), providing important data such as sex (male/female) and tumor types, and describes the frequency of ameloblastoma and odontoma in an engaging manner, while emphasizing the importance of clinical features.
I have some suggestions that the authors might consider:

  1. Modify the title, for example:
    "Odontogenic Tumors in Pediatric and Adolescent populations: A Scoping Review"
    "Odontogenic Tumors in Populations under twenty years Old: A Scoping Review"
    (That would be more aligned with the methodology of the manuscript.)

  2. For the PRISMA-ScR Chart (Figure 1), I suggest including a figure caption, such as: "Figure 1”: PRISMA-ScR Chart depicting the selected items from the reviewed articles."

  3. In the conclusion, it would be beneficial to highlight the importance of this study for including pediatric odontogenic tumors in new versions of the WHO classification. Additionally, emphasize the significance of this study as the first comprehensive review of manuscripts focused on odontogenic tumors in the pediatric population.

Source

    © 2024 the Reviewer.

Content of review 2, reviewed on January 09, 2025

Dear Editor,
Thank you for the opportunity to reassess this interesting and valuable manuscript, in which the authors have responded precisely and effectively to all the suggestions made by the reviewers. The manuscript has undergone significant improvement compared to its previous version.
I believe this work is innovative in its approach to odontogenic tumors in pediatric and adolescent populations. The authors involved in its development are part of a distinguished international consortium and are recognized as leaders in the study of these pathologies, further supporting the relevance of the article.

The manuscript addresses highly important clinical aspects, including the prevalence of benign and malignant tumors, as well as a detailed description of specific lesions such as odontomas and ameloblastomas. It highlights that 99.5% of the tumors analyzed are benign, while malignant tumors, although rare, include entities such as ameloblastic carcinoma and ameloblastic fibrosarcoma, which represent approximately 0.5% of the cases evaluated. Additionally, the analysis of clinical variables provides a solid foundation that can guide the evaluation and clinical management of odontogenic tumors in the pediatric population.
I am convinced that this article will become a key reference for the next update of the WHO classification of odontogenic tumors. For the reasons stated and considering that the authors have adequately addressed the observations made, I recommend its publication.

Source

    © 2025 the Reviewer.

Content of review 3, reviewed on February 20, 2025

The manuscript has been improved

Source

    © 2025 the Reviewer.

References

    Frenzel, S. L., David, H. K., Kelly, M., Willie, v. H., Liam, R., Ann, B. E., Mohd, H. H., Merva, S., Olumuyiwa, A. A., Mudiyanselage, T. W., Jiang, L., Santiago, G. R., Ronell, B. 2025. Odontogenic Tumors in Pediatric and Adolescent Populations: A Scoping Review. Oral Diseases.