Content of review 1, reviewed on November 14, 2023
In this study, the authors report an organocatalyzed cascade Michael/Michael reaction between isatylidene malononitrile and α, β-unsaturated ketones to deliver a series of compounds featuring spiro[3-arylcyclohexanone]oxindoles. The author also increased the transformation efficiency by using a continuous-flow system. However, there are too many reports with better results developed by other groups, even asymmetric version of this transformation (ref. 13f). The only finding is using L-proline as the amine organocatalyst in this reaction. The reaction time was decreased to less than 2 h by continuous-flow. However, these were preliminary results, which could be optimized by other conditions, such as heating or changing the tubing with different diameters, and so on. Therefore, the reviewer suggests it is not suitable published in RSC Advances.
Source
© 2023 the Reviewer.
References
R., P. B., B., N. C., S., C. S., Rama, K. G., K., K. A. 2024. Organocatalyzed [4+2] cycloaddition of α,β-unsaturated ketones and isatylidene malononitrile: accessing spiro[3-arylcyclohexanone]oxindole derivatives. RSC Advances.
