Thank you for the opportunity to read this interesting manuscript about how the definition and regulation of advanced practice nursing varies across European countries. I think this manuscript presents valuable cross-sectional data points about advanced practice nursing roles across Europe that can be compared to future data points as advancements are made in defining and regulating APNs. I have some comments for consideration.

Methods:
-I suggest stating a specific research question that guided the study.

Discussion:
-How do the regulatory bodies overseeing advanced practice nursing in European countries compare with those in the U.S., in which nursing practice limitations vary by state?
-What are some immediate next steps that should be taken to developing the consistency of APN definitions and regulations across European countries?

Thank you for addressing my comments. I have no further comments.