In this article, the authors summarize the application of minimally invasive spine surgery in the treatment of spinal metastatic tumors from the concept, surgical purpose, indications, and surgical selection, providing reference for clinical practice. The manuscript is straightforward, well written, and concise and has clear results within the scope of a review article. Definitely deserves to be published and is a valuable contribution to the “Technology in Cancer Research & Treatment” journal. Some minor comments need to be addressed before publication.

[1] “1. Introduction”, Page 2 of 23, Lines 20-28:
“With the wide application of targeted therapy, immunotherapy, stereotactic radiotherapy and other technologies, the prognosis of patients with malignant tumors has been significantly improved, which makes more patients with spinal metastases need surgical treatment.”.
At that point, the authors should mention that chemotherapy may also be an effective initial treatment option, even in the presence of severe and relatively acute spinal cord compression. For example, Ewing sarcoma is considered as systemic, requiring a combination of surgery or RT for localized control and high-intensity chemotherapy for localized and disseminated disease. Theoretically, chemotherapy reduces micrometastases and, therefore, contributes to improved survival, from a biological point of view.
Recommended reference: Boussios S, et al. Spinal Ewing Sarcoma Debuting with Cord Compression: Have We Discovered the Thread of Ariadne? Anticancer Res. 2018;38(10):5589-5597.

[2] “4.5 Radiofrequency ablation”, Page 11 of 23, Lines 10-18:
“Indications of radiofrequency ablation for spinal metastatic tumors: patients with long expected survival (>6 months) are not suitable for open surgery due to various reasons; no spinal cord, nerve root compression or there are symptoms of nerve root compression but refuse to undergo open surgery; no more than 3 vertebrae treated at one time.”.
Currently, there is low level of evidence for the superiority of stereotactic radiosurgery (SRS) over conventional fractionated radiation or decompressive surgery. Nevertheless, it should be mentioned that SRS and stereotactic body RT of metastases in the spine, are considerably safe with reported low risk of grade 3 toxicity, including nausea, vomiting, diarrhea, fatigue, trismus and pain.
Recommended reference: Boussios S, et al. Metastatic Spinal Cord Compression: Unraveling the Diagnostic and Therapeutic Challenges. Anticancer Res. 2018;38(9):4987-4997.

I had recommended on the first round revision to be mentioned that chemotherapy may also be an effective initial treatment option, even in the presence of severe and relatively acute spinal cord compression. Please, provide the example of Ewing sarcoma, in which is considered the combination of surgery or RT along with high-intensity chemotherapy. Theoretically, chemotherapy reduces micrometastases and, therefore, contributes to the treatment.

Recommended reference: Boussios S, et al. Spinal Ewing Sarcoma Debuting with Cord Compression: Have We Discovered the Thread of Ariadne? Anticancer Res. 2018;38(10):5589-5597.

The authors responded adequately to my comments.
I recommend the acceptance of the current revised version.
Congratulations on the great work.