This is a timely manuscript on implementation of concurrent electrical stimulation and recording functions, which are becoming increasing important for new generation of adaptive DBS. This manuscript includes a nice and comprehensive introduction to this important neural engineering problem, a list of configuration settings to improve system performance and areas for future device improvement, and extremely valuable data from human subjects with DBS implants. The manuscript is very well organized, the results are well presented and illustrated.
Minor points:
In addition to aDBS, another important application of concurrent stimulation and sensing is in neural prostheses such as motor prostheses, sensory prostheses, and cortical prostheses, where neural recording after stimulation is almost required for successful implementation of these systems. It would be helpful if authors can discuss about the implication of the technologies described in this study on these prosthetic devices. In fact, the boundary between some cortical prostheses and DBS can even be unclear. For example, hipppcampal memory prostheses also require both stimulation and recording capabilities. The insights described in this manuscript can be extremely valuable for making those new types of the brain modulation techniques clinically viable.
In aDBS described in this study, biomarkers are extracted mainly from LFP. I’m also curious about whether the concurrent stimulation and sensing capability described here can be extended to recording of neural spiking activities, which is necessary in motor prostheses and cortical prostheses.
Finally, the artifact suppression techniques utilized in this study are all relative mature and well-established. There are a lot of new development in this field. such as using active or even model-based artifact cancellation for allowing real concurrent recording and stimulation (i.e., recording neural signals even during the stimulation pulses). I would like to hear authors’ opinions on these emerging techniques and their implication to aDBS.

Authors have sufficiently addressed my questions.