Content of review 1, reviewed on January 26, 2022
The manuscript submitted by Yang and co-workers describes the catalyst free decarboxylation of 4-hydroxycinnamic acid to produce vinylphenols. There are several existing methods in the litrature to convert substituted cinnamic acid to vinylphenols through decarboxylation however present manuscript desmonstrate a catalyst free decarboxylation of 4-hydroxycinnamic acids which offers an interesting and practical protocol. The manuscript can be accpeted after major rivision with considering below mentioned points.
- Authors used variety of 4-hydroxycinnamic acid in this manuscript. Did authors attempt to use cinnamic acid having thio (SH) or amino (NH2) groups on para position to check reactivity as this would open the wide scope of this methodlogy.
- In the manuscript authors should clearly mention, they have used trans-cinnamic acid or mixure of cis/trans cinnamic acids for the decarboxylation (it appears they have used trans cinnamic acid). Does the geometry of cis or trans cinnamic acid influence the decarboxylation?
- In supporting information authors must provide the general information about purity, source of chemicals used for the reactions, instruments used to analysed the products using 1H and 13 NMR, HR-Mass spectrometer and all other important information for readers to reproduce the reactions.
- In SI, 1H and 13 NMR should be labeled with proper heading i.e. 1H or 13C NMR (DMSO-d6 or CDCl3, 400/100 MHz) spectrum of xx.
- The figures and tables must be distinctly incorporated in the manuscript having alignment with text for better understanding of readers.
- There are some typo mistakes in the manuscript for example in introduction, second paragraph, line 2, “plomers” should be “polymers”.
- The title of first part of manuscript should be “Abstract” but not “Summary”.
Source
© 2022 the Reviewer.
References
Qian, Y., Youjuan, L., Huanhuan, L., Enhua, W., Mei, P., Tingfei, D., Xiong, P., Zhongsheng, L., Yanfang, Y., Lishou, Y., Xiaosheng, Y. 2022. Catalyst-free decarboxylation of 4-hydroxycinnamic acids: efficient synthesis of 4-vinylphenols. Royal Society Open Science.