Content of review 1, reviewed on April 21, 2021
Overall -Complete and can be considered for publication with minor revision Overall good article and helpful for research and development lab to method transfer to small lab.
Major points - Diclofenac is very old molecule and there many more numbers of article on HPLC. Author have to do extensive literature review and incorporate the all the references in text of manuscript as well as reference section of manuscript. Study Claims all dosage form but study is done on only tablet dosage form can be applied to other dosage form by method verification one time during method transfer activity
Minor - Inclusion of empirical formula and molecular weight and robustness variations
Abstract - Ok Title- Ok References' - Ok as per journals guidelines
In Introduction Molecule Diclofenac empirical formula and molecular weight is missing as well salt form is used for further analysis hence DS. empirical formula and molecular weight need to be included for better Introduction part.
Methodology Overall up to mark and need minor clarification and inclusion Variable used in robustness need to defined in method section and how many parameter are changed in chromatographic condition need to be more clear and precise
Data and Result Ok as per ICH Guidelines and complies guidelines and acceptable
Discussion - Study Claims all dosage form but study is done on only tablet dosage form can be applied to other dosage form by method verification one time during method transfer activity Author need to show comparison between proposed method and published one
Conclusion - Can also include stability of solution and robustness of method incorporate advantages of proposed method over the published one in conclusion section of original manuscipt Review Done and adressed Feedback
Source
© 2021 the Reviewer.
References
Tuwfeeq, A. B. 2019. Development and validation of a new HPLC analytical method for the determination of diclofenac in tablets. Saudi Pharmaceutical Journal.