I have some corrections to improve the article value that I describe in the following comments:

Six coronaviruses reported as human-affected viruses include α- coronaviruses NL63 and 229E, low-pathogenic β-coronaviruses OC43 and HKU1, these viruses cause mild respiratory symptoms as common cold [2]. The remaining two types were identified as β-coronavirus, which unusually induced fatal respiratory tract infections [3].

Q1. In those aforementioned sentences, author mentioned six types of coronavirus, but author just describe four types “α-coronaviruses NL63 and 229E, low-pathogenic β-coronaviruses OC43 and HKU1”. Even though author mentioned the remaining two types were identified as β-coronavirus however author did not mention these two types, my suggestion is better to put remaining two types were identified as β-coronavirus

Q2. First paragraph in sentence “Between 2002 and 2003, severe acute respiratory syndrome (SARS) resulted in the outbreak of SARS0[4]….Please correct typos of SARS0

Q3. Paragraph 3 “On the same day, the international committee of taxonomy named this virus as SARS-CoV-2 and classified it as coronavirus under the family Coronaviridae, subfamily Orthocoronavirinae, based on the genotypic and serological characterization”. Please correct the sentence and give the abbreviation of international committee on taxonomy of virus (ICTV)”

Q4: Why author just focused on the Cytokine and ACE-2, currently there are so many gene that was reported such as TMPRSS2. It will be better if author include explanation of TMPRSS2 as well.

Hoffmann, H. Kleine-Weber, S. Schroeder, N. Kruger, T. Herrler, S. Erichsen,T.S. Schiergens, G. Herrler, N.H. Wu, A. Nitsche, M.A. Muller, C. Drosten,S. Pohlmann, SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and isblocked by a clinically proven protease inhibitor, Cell 181 (2) (2020) 271e280,https://doi.org/10.1016/j.cell.2020.02.052 Irham LM, Chou WH, Calkins MJ, Adikusuma W, Hsieh SL, Chang WC. Genetic variants that influence SARS‐CoV‐2 receptor TMPRSS2 expression among population cohorts from multiple continents. Biochem Res Commun. 2020;529(2):263‐269.

Q5. Author mentioned “ SARS-CoV-2 may induce liver injury via a similar mechanism”. Which is the similar mechanis?. As reader I could not identified which mechanism

Q6: Please cite the reference in the sentence” Patients with digestive issues and co-infected with SARS-CoV-2 show a higher risk of mortality than patients without digestive problems.”

Q7: In part of Hepatitis B and COVID19. Author mentioned that “For patients with chronic hepatitis B and are in the immune tolerance phase, further tests are required to confirm whether these patients have active viral replication and repeated liver damage after co-infection with SARS-CoV-2” It is important point to elaborate more detail the Hepatitis B and COVID-19 in immune tolerance phase. It is better to mention the characterize of Immune intolerant phase. In this phase (immune tolerance phase) characterize by high level of HBV biomarkers such as HBsAg and HBeAg, but low level of ALT. it is mostly indicated the low inflammatory in this phase.

Q8: In conclusion in the sentence “In this review, we concluded that the most destructive power of the virus is the generation of violent cytokine storm, which is probably the cause of high mortality rates in hepatic and nonhaptic patients”. I think it is better to not use the most destructive power of the virus is the generation of violent cytokine storm. Because current study does not perform analysis that reflect the most destructive power of the virus is the generation of violent cytokine storm,

Brief overview of the paper and its main findings

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Major and minor points

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Conflicts of interest

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