This is a clear, concise, and well-written manuscript. The introduction is relevant and theory based. Sufficient information about the previous study findings is presented for readers to follow the present study rationale and procedures. The methods are generally appropriate. The process of subject selection is clear. The variables are defined and measured appropriately. The study methods are valid and reliable.. The results are clear. The data presented in an appropriate way. Tables and figures relevant and clearly presented. Titles, columns, and rows labelled correctly and clearly. Categories grouped is appropriate. The text in the results add to the data. The results discussed from multiple angles and placed into context without being overinterpreted. The conclusions answer the aims of the study. The authors make a systematic contribution to the research literature in this area of investigation. The limitations of the study give opportunities to inform future research. Overall, this is a high quality manuscript that has implications for the theoretical basis and development of anti-HCV drugs candidates.