Content of review 1, reviewed on January 18, 2021
The paper “Perimplantitis-like MRONJ: clinical considerations and histological evaluation with confocal laser scanning microscope” is a nice work investigating clinical, radiological, and histological features of peri-implant MRONJ (PI-MRONJ). In particular, the authors reported a series of 19 osteoporotic patients undergoing antiresorptive drugs with a previous diagnosis of perimplantitis affected by PI-MRONJ. The results are interesting, suggesting that perimplantitis not healed after conventional therapy in patients at risk on MRONJ occurrence should be considered as perimplantits-like PI-MRONJ, and treated as required.
The reported clinical data are accurate and complete and clearly synthesized. The amount of photographic, radiographic, and histological data is adequate. Moreover, the authors conducted a comprehensive literature review on this topic.
Overall, I think the paper is interesting. However, I suggest few comments about this study:
Introduction: The Introduction section is too long. I suggest shortening this section, in particular the detailed discussion about the definition of perimplantitis.
Results: delete the percentages (if n < 100, the use of percentage implies a spurious impression of accuracy).
Delete the references “(Favia et al., 2011; Favia, Pilolli, & Maiorano, 2009)” in this section, or move them to Discussion.
Minor:
Please add “3)” in the description of patterns of bone involvement in PI-MRONJ (page 5 and page 10).
Introduce the extended name of the acronyms “BPs” (page 9).
Few minor language corrections should be necessary.
Source
© 2021 the Reviewer.
Content of review 2, reviewed on March 15, 2021
The authors made several changes, improving the quality of the manuscript.
Source
© 2021 the Reviewer.
References
Angela, T., Saverio, C., Rodolfo, M., Dorina, L., Eugenio, M., Gianfranco, F., Luisa, L. 2022. Peri-implantitis-like medication-related osteonecrosis of the jaw: Clinical considerations and histological evaluation with confocal laser scanning microscope. Oral Diseases.