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publons.com/wos-op/p/50691892/
doi.org/10.1111/PIM.12920
pubmed.ncbi.nlm.nih.gov/35430739
Web of Science (Free Access)
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Abstract

Strongyloidiasis is a chronic and asymptomatic infection in immunocompetent patients. Immunocompromised patients, such as organ transplant candidates, can develop severe forms of this disease, and the best way to prevent progression to these forms is early diagnosis. Serological techniques using specific IgG and immune complexes (IC) detection can help in the diagnosis of these patients. This study aimed to detect specific anti-Strongyloides IC and IgG antibodies in kidney transplant (KT) and liver transplant (LT) candidates. A total of 100 blood samples was collected from transplant candidates (50 blood samples each from KT and LT candidates). Serum was obtained and analysed using enzyme-linked immunosorbent assay for IC and IgG detections. The IC levels showed frequencies of 18% and 2% in the KT and LT groups, respectively, whereas anti-Strongyloides IgG was detected in 34% and 12% of KT and LT candidates, respectively. The correlation between IC and IgG detection is poor in KT candidates, while in LT candidates, there is a significant positive correlation. The detection of IC can be an additional tool for the diagnosis of strongyloidiasis, especially when associated with the detection of specific IgG anti-Strongyloides antibodies.

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Authors

Corral, Marcelo A.;  Goncalves, Ana Lucia R.;  Costa, Idessania N.;  Abdala, Edson;  Pierrotti, Ligia C.;  Chieffi, Pedro Paulo;  Costa-Cruz, Julia Maria;  Gryschek, Ronaldo Cesar B.;  Paula, Fabiana Martins

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  • pre-publication peer review (FINAL ROUND)
    Decision Letter
     2022/04/11

    Dear Dr Martins de Paula

    Re: PIM-2021-0081.R2 Immune complexes as a tool for strongyloidiasis immunodiagnosis in kidney and liver transplant candidate

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    Author Response
     2022/04/07

    Dear Professor Richard Grencis

    Editor Parasite Immunology
    We appreciate the comments. All suggestions were accepted.
    We are forwarding a highlighted version, a clean version and the review certificate.

    Reviewer: 1

    Comments to the Author
    The paper should be reviewed and edited by a native English speaker
    Thanks. The manuscript has been revised and edited by an English speaker, as suggested.

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  • pre-publication peer review (ROUND 2)
    Decision Letter
     2022/03/28

    Dear Dr Martins de Paula

    We recognise that the impact of the COVID-19 pandemic may affect your ability to return your revised manuscript to us within the requested timeframe. If this is the case, please let us know.

    PIM-2021-0081.R1 Immune complexes as a tool for strongyloidiasis immunodiagnosis in kidney and liver transplant candidate

    Thank you for submitting your manuscript to Parasite Immunology. We have now received the reviewers’ comments, copies of which are attached.

    As it stands, the manuscript is not quite suitable for publication, but if you can respond to the comments raised by the reviewers, your paper would be acceptable for publication.

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    Once again, thank you for submitting your manuscript to Parasite Immunology and I look forward to receiving your revision.

    With kind regards

    Professor Richard Grencis
    Editor
    Parasite Immunology

    In addition to the referee comments below please note we have added the following to our Instructions to Authors:

    "Disclosures. For each author, disclose potential conflicts of interest, including all relevant financial interests (e.g. employment, significant share ownership, patent rights, consultancy, research funding) in any company or institution that might benefit from the publication (or state 'none'). Authors do not need to report the sums concerned."

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    Reviewer(s)' Comments to Author:

    Reviewer: 1

    Comments to the Author
    The paper should be reviewed and edited by a native English speaker

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    Decision letter by
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    Reviewer report
     2022/03/24

    The paper should be reviewed and edited by a native English speaker

    Reviewed by
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    Author Response
     2022/03/03

    Dear Professor Richard Grencis
    Editor Parasite Immunology
    We appreciate the comments. All suggestions were accepted and inserted into the manuscript.

    Reviewer: 1

    Comments to the Author
    No comments
    Thanks.

    Reviewer: 2

    Comments to the Author
    An article of interest examining the use of immune complexes for the detection of Strongyloides infections ion patients receiving liver or kidney transplants.
    We appreciate the comments. All suggestions were accepted and inserted into the manuscript.

    1. A diagnostic assay is validated by estimating sensitivity and specificity against a gold standard. Without this validation process, it is difficult to evaluate the usefulness of measuring ICs.
      Both techniques were validated, with 93.3 and 100% of sensitivity, and 86.1 and 95.4% of specificity, by IC and IgG respectively. This information was addition in material and methods (Lines 113-114 and 127-128).

    2. While some individuals were IC-positive and not IgG-positive, it is not clear what are the practical recommendations of the authors. Do they suggest measuring both specific IgG and ICs, measuring specific IgG, ICs, and doing parasitology on all liver and kidney transplant patients? If the latter is the case, do they recommend treatment for S. stercoralis for anyone testing positive with any of the 3 assays or what?
      It would be desirable to evaluate a combination of diagnostic techniques (serology, IC, parasitological and PCR), in an ideal scenario. However, in the case of availability of serology or IC only, we would propose treatment with any of the positive techniques alone.
      This proposal was added at the end of the manuscript (Lines 192 to 196).

    3. Seropositivity for specific IgG among kidney transplant patients was stated as 64% (line 152) but 17/50 had ‘positive’ IgG (EI>1), etc, in Figure 2. These discrepancies need to be reviewed.
      We apologize for the error. This information has been corrected (Lines 38 and 152).

    Author response by


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  • pre-publication peer review (ROUND 1)
    Decision Letter
     2022/02/02

    Dear Dr Martins de Paula

    We recognise that the impact of the COVID-19 pandemic may affect your ability to return your revised manuscript to us within the requested timeframe. If this is the case, please let us know.

    PIM-2021-0081 Immune complexes as a tool for strongyloidiasis immunodiagnosis in kidney and liver transplant candidate

    Thank you for submitting your manuscript to Parasite Immunology. We have now received the reviewers’ comments, copies of which are attached.

    As it stands, the manuscript is not quite suitable for publication, but if you can respond to the comments raised by the reviewers, we would be very pleased to look at a revised version of your paper.

    Before submitting your revisions, please prepare the following documents:

    1. A cover letter giving a point-by-point response to the reviewers' concerns. In order to expedite the processing of the revised manuscript, please be as specific as possible in your response.

    2. A revised manuscript (word document), highlighting all the changes made in the document. Please try to address all of the concerns raised by the reviewers within the manuscript. Should you disagree with the reviewers' comments, please provide explanations.

    3. A “clean” version of your revised manuscript where the changes are not marked.

    Please be sure to format your revised manuscript according to the journal guidelines for authors at https://onlinelibrary.wiley.com/page/journal/13653024/homepage/forauthors.html.

    To submit your revised manuscript:

    Our journal is currently transitioning to Wiley’s Research Exchange submission portal. Please read these instructions carefully.

    If you submitted your manuscript through our Research Exchange site, you will see a link below to submit your revised manuscript:
    https://wiley.atyponrex.com/submissionBoard/1/a946af6a-17b7-414a-8602-b1775bc48544/current

    (If no link appears, follow the instructions in the next paragraph.) Click on the link or go to wiley.atyponrex.com/journal/PIM. Sort by journal and submission status to locate this manuscript, then click the “Revise submission” button to submit your revision. You will be able to respond to the reviewer comments when asked to “Upload your Author Response”. All supplementary and additional files will be carried over when you submit a revised manuscript. You may be required to provide additional files at the revision stage.

    If you submitted your manuscript through ScholarOne, please use this link to submit your revised manuscript:
    *** PLEASE NOTE: This is a two-step process. After clicking on the link, you will be directed to a webpage to confirm. ***

    https://mc.manuscriptcentral.com/pim?URL_MASK=c0f17fbaddd544b9b82c82acf0ce3627

    Click on the link or go to https://mc.manuscriptcentral.com/pim and enter your Author Center, where you will find your manuscript title listed under "Manuscripts with Decisions." Under "Actions," click on "Create a Revision”. You will be able to respond to the comments made by the reviewer(s) in the space provided. Your original files are available to you when you upload your revised manuscript. Please delete any redundant files before completing the submission manuscript’s Manuscript ID number in the space below” and include your original submission's Manuscript ID number (PIM-2021-0081) where indicated.

    When submitting your revised manuscript, you will be able to respond to the reviewer comments when asked to “Upload your Author Response”.

    Upload your new revised manuscript files. All supplementary and additional files will be carried over when you submit a revised manuscript. You may be required to provide additional files at the revision stage. If indicated to do so, please upload any additional required files as needed.

    Please be sure to double-check everything carefully so that your manuscript can be processed as quickly as possible.

    Wiley Editing Services Available to All Authors
    Should you be interested, Wiley Editing Services offers expert help with manuscript, language, and format editing, along with other article preparation services. You can learn more about this service option at www.wileyauthors.com/eeo/preparation. You can also check out Wiley’s collection of free article preparation resources for general guidance about writing and preparing your manuscript at www.wileyauthors.com/eeo/prepresources.

    This journal offers a number of license options for published papers; information about this is available here: https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/index.html. The submitting author has confirmed that all co-authors have the necessary rights to grant in the submission, including in light of each co-author’s funder policies. If any author’s funder has a policy that restricts which kinds of license they can sign, for example if the funder is a member of Coalition S, please make sure the submitting author is aware.

    Because we are trying to facilitate timely publication of manuscripts submitted to Parasite Immunology, your revised manuscript should be uploaded as soon as possible, and by 05-Mar-2022 at the latest. If it is not possible for you to submit your revision by the due date, we may have to consider your paper as a new submission. If you feel that you will be unable to submit your revision within the time allowed please contact the editorial office to discuss the possibility of extending the revision time.

    Once again, thank you for submitting your manuscript to Parasite Immunology and I look forward to receiving your revision.

    With kind regards

    Professor Richard Grencis
    Editor
    Parasite Immunology

    In addition to the referee comments below please note we have added the following to our Instructions to Authors:

    "Disclosures. For each author, disclose potential conflicts of interest, including all relevant financial interests (e.g. employment, significant share ownership, patent rights, consultancy, research funding) in any company or institution that might benefit from the publication (or state 'none'). Authors do not need to report the sums concerned."

    Please can you therefore add a small paragraph on the title page of your paper (underneath the details for correspondence) entitled "Disclosures" and then include any relevant details or "none" if there is nothing to disclose, if you have not already done so.

    Should your manuscript be accepted for publication you will be required to publish a data availability statement to confirm the presence or absence of shared data. Please could you therefore include an appropriate Data Availability Statement and, if necessary, add a data citation to your manuscript.

    Please see the following link for further information and sample statements you may use: https://authorservices.wiley.com/author-resources/Journal-Authors/open-access/data-sharing-citation/data-sharing-policy.html

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    Reviewer(s)' Comments to Author:

    Reviewer: 1

    Comments to the Author
    No comments

    Reviewer: 2

    Comments to the Author
    An article of interest examining the use of immune complexes for the detection of Strongyloides infections ion patients receiving liver or kidney transplants.

    1. A diagnostic assay is validated by estimating sensitivity and specificity against a gold standard. Without this validation process, it is difficult to evaluate the usefulness of measuring ICs.
    2. While some individuals were IC-positive and not IgG-positive, it is not clear what are the practical recommendations of the authors. Do they suggest measuring both specific IgG and ICs, measuring specific IgG, ICs, and doing parasitology on all liver and kidney transplant patients? If the latter is the case, do they recommend treatment for S. stercoralis for anyone testing positive with any of the 3 assays or what?
    3. Seropositivity for specific IgG among kidney transplant patients was stated as 64% (line 152) but 17/50 had ‘positive’ IgG (EI>1), etc, in Figure 2. These discrepancies need to be reviewed.

    Get Content Alerts from Parasite Immunology:

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    Decision letter by
    Cite this decision letter
    Reviewer report
     2022/02/01

    An article of interest examining the use of immune complexes for the detection of Strongyloides infections ion patients receiving liver or kidney transplants.

    1. A diagnostic assay is validated by estimating sensitivity and specificity against a gold standard. Without this validation process, it is difficult to evaluate the usefulness of measuring ICs.
    2. While some individuals were IC-positive and not IgG-positive, it is not clear what are the practical recommendations of the authors. Do they suggest measuring both specific IgG and ICs, measuring specific IgG, ICs, and doing parasitology on all liver and kidney transplant patients? If the latter is the case, do they recommend treatment for S. stercoralis for anyone testing positive with any of the 3 assays or what?
    3. Seropositivity for specific IgG among kidney transplant patients was stated as 64% (line 152) but 17/50 had ‘positive’ IgG (EI>1), etc, in Figure 2. These discrepancies need to be reviewed.

    Reviewed by
    Cite this review
    Reviewer report
     2021/12/23

    No comments

    Reviewed by
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