Content of review 1, reviewed on August 07, 2014

This manuscript describes a fairly comprehensive study investigating links between nutrient intake and DNA methylation of a small number of genes in the context of obesity. The authors correctly note that it is an exploratory study with a number of limitations (for example, the assessment of nutrients was only semiquantitative), and that further studies would benefit from additional analyses (for example, a genome-wide approach). Nevertheless, I believe the study will be of interest to readers of Nutrients, and is particularly relevant for a special issue on nutritional epigenetics. My main concern is with the language of the manuscript, in which there are numerous typographical and grammatical errors. For example: [1] Title should read: "Nutrient intake" or "Intake of nutrients", rather than "Nutrients intake" [2] Line 25: The first sentence of the abstract should read: "The aim of the present study was to evaluate DNA methylation alterations induced by dietary nutrients in a population of overweight/obese subjects" [3] Line 29 of the abstract (and elsewhere): The blood clinical parameters should be in lower case unless they are abbreviated (i.e., they should read: "total cholesterol, LDL, HDL, triglycerides, homocysteine"). [4] Line 34 of the abstract (and elsewhere): "We observed positive significant associations" should read: "We observed significant positive associations" [5] Line 54: "in the last years a great effort" should read: "in recent years a great effort" [6] Line 55: "Among antioxidants, carotenoids have been shown free radicals scavenger properties..." should read: "Among antioxidants, carotenoids have been shown to act as free radical scavengers..." The manuscript requires extensive editing of the English language and style. If this is attended to, I believe it would be suitable for publication.

Source

    © 2014 the Reviewer (CC BY 4.0).