Content of review 1, reviewed on April 23, 2020
Author/s’ experience
Very actual study that brings new information to fill in the gap on the histological features of lungs in those who died of COVID-19. The data are presented by experienced authors.
Methodology
The paper seems methodologically correct and based on multicentre (2 hospitals) study with histological assessment performed by 2 pathologists blinded to the results of each other. For better compliance GPP, I would suggest to add the information of immediate cause of death to the description of the study population; the results of analysis of concordance of the results of tissue evaluation performed by 2 pathologists, who were involved to the study. As pre-existing chronic obstructive pulmonary disorders are described in 3 patients, could these cases influence the results of pulmonary fibrosis assessment? It would be nice also, if the past-malignancies localizations also were described.
Conflicts of interest
I have no conflict of interests in the regard to this review.
Basis of the findings
The statement are logical and are based on the described results. This study is rather explorative by nature and larger studies are necessary to make an association between different aspects that characterize the disease flow (including co-morbid pathologies, medications used, laboratory deviations, etc) with histological features observed in pulmonary tissues much clear.
Source
© 2020 the Reviewer (CC BY 4.0).