Basic reporting

No comments

Experimental design

The experimental design is very good and properly described.

Validity of the findings

The finding are very well supported and the iconography is excellent!

Comments for the author

I agree that the author have demonstrated that endothelia covering-type extravasation happens in absence of VEGF and therefore is likely to be one of the factors allowing tumour progression under anti VEGf treatment. I also agree that they have demonstrated that more cells extravasate. I am only doubtful whether this account for a more aggressive tumour as, after all, the invasion type is instead absent absent. Perhaps the author could briefly comment on this issue instead of concluding that could explain a more aggressive behaviour.