Review of Dominant-negative CARD11 loss-of-function variant presenting with hypereosinophilic syndrome

Content of review 1, reviewed on August 31, 2023

The LTE submitted to PAI journal describes a case of a patient with hypereosinophilic syndrome linked to a heterozygous pathogenic nonsense variant in CARD11.
Minor suggestions:

1) Please provide more information on biopsies done and results of hpf. Why was it initially diagnosed as Ulcerative colitis ?
2) Include a timeline on age of onset of clinical symptoms and treatments to increase clarity.
3) Consider adding a table or figure with lab results.
4) Expand on the diagnosis of recurrent osteomyelitis.

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E., W. B., Payge, V. S., Rachel, M., Nikita, G., Nicole, S., S., B. C., A., S. K. 2023. Dominant-negative CARD11 loss-of-function variant presenting with hypereosinophilic syndrome. Pediatric Allergy and Immunology.

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Dominant-negative CARD11 loss-of-function variant presenting with hypereosinophilic syndrome

Reviewed On August 31, 2023

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Content of review 1, reviewed on August 31, 2023

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