Content of review 1, reviewed on April 28, 2020

-Title: "Predictors of Mortality in Staphylococcus aureus Bacteremia" Comment : Title is suitable with the content of research but the aim is not clear in it .

-Abstract Section: *Summary: Staphylococcus aureus bacteremia (SAB) is an important infection with an incidence rate ranging from 20 to 50 cases/100,000 population per year. Between 10% and 30% of these patients will die from SAB. Comment: It is important note about this percantage and requeres to explain the reasones . Comment:The abstract should be separated into background, aims and conclusion. Comment:It has no aims.

-Introduction Section : Section: The incidence of SAB increases with advancing age, with the lowest rates observed in pediatric populations, at approximately8.4/100,000 population per year. Comment:It is depending on many factors like health rate , age group, immune response

Mortality Section:The purpose of this review is to examine factors that influ-ence mortality and investigate the relative impact of each factor onoutcomes for patients with SAB. Comment:The Misuse and Overuse of antibiotics play an important role with increase the complications and then the mortality rate.

Age Section: the increased mortal-ity from SAB associated with aging is directly linked to changeswithin the host as a consequence of the aging process, and ageremains a significant confounder when examining other variablesthat influence outcomes . Comment:It is also associated with the decrease in the immune state of patients .

Age section (host factors): is the most consistent and strongest predictor of all-cause and infection-related 30-day mortality, with the majority of SAB cohort studies using multivariate analysis, confirming age as an independent predictor of mortality. Comment :The age group of children very susceptible to any type of bacteremia.

Gender Section: The incidence of SAB is generally higher for males than for females. Comment: Clarification the reasones.

-Table 1 Summary of studies that have examined the impact of age on mortality in cases of Staphylococcus aureus bacteremia Comment: Table 1 have more information that must be arrangement.

--Fig 1 :Impact of age on overall 30-day mortality from Staphylococcus aureus bacteremia. Percentages of patients who succumbed at 30 days following an episode of Staphylococcus aureus bacteremia are stratified by 10-year age groups. (Adapted from reference 155 with permission of Elsevier. Comment : Fig 1 not clear and has no more title for columns.

Socioeconomic status (SES): is known to impact a patient's infection risk Comment: Socioeconomic status was not important in this research.

Immune Status :Immunosuppression can be defined as a congenital or acquiredquantitative or qualitative deficiency of phagocytic cells, comple-ment, or humoral or cell-mediated immunity.
Comment:Explain which type of immunity( innate or humoral) more effective for this study.

Bacteruria : S. aureus is an uncommon uropathogen in the absence of bladdercatheterization, instrumentation, or surgery and thus typicallyrepresents hematogenous spread. Comment: Explain the mechanisms of this bacteria on UTI.

Table 3 :Summary of studies that have examined the impact of severity of illness on mortality in Staphylococcus aureus bacteremia Comment : Table 3 has a short name within the table. it was not cleared.

conclusions: Comment: This paper has no conclusions.

References: Comment: Introduction has more references compare with other sections of the research . Comment: Modren references should be distributed on each section of the research.

Source

    © 2020 the Reviewer.

References

    J., v. H. S., O., J. S., L., V. V., A., E. B., L., P. D., B., G. I. Predictors of Mortality in Staphylococcus aureus Bacteremia. Clinical Microbiology Reviews.