The authors have improved the manuscript and addressed most points raised by the reviewers. However, changes in the figures are still required, apart from an extensive language revision. - Supplementary figures have a better resolution that the figures in the manuscript. - Figure 1B and, to a lesser extent, 1A are still unreadable because of their low resolution even though the figure is almost 10 mb in size. I am afraid that increasing the size of the file will not fix the issue at this point and I recommend re-starting from scratch. - Figure 5D: Please correct "Glyphotate" with "glyphosate" - Figure 7B: Please, change chorismate acid with "chorismic acid" or "chorismate", depending on what was measured. Metabolites are not "expressed" please, change "relative expression level" in the figure and "Compounds contents" in the legend with "relative metabolite levels" - Figures 2 and 5: Color not needed. - Line 36. "Revealed". Correct. - Line 118, 431 and Figure 1 legend. "Bioinformatics analysis". Correct. - Line 336. space between I. and indigotica. - Line 386. Catalytic, Correct. "in vitro", all italics. - Through the manuscript: "Root hairs" and "root hairss" are incorrect terms. Please, replace with "hairy roots". - Figure 1 legend, remove sequences at the end and replace species of plant with "plant species" - Figure 2 legend: Induction, correct. - Figure 3 legend. I. indigotica, separate. - Figure 5 legend. "in vitro" all in italics. Correct - Figure 6 legend. replace root hairss with "hairy roots", steriled with sterilised, I.indigotica, separate. - Figure 7 legend. Root hairss is incorrect. replace with hairy roots as in the rest of the manuscript. respecitively is incorrect, replace with respectively.