Content of review 1, reviewed on April 22, 2020

The research objective was clearly stated. The population and inclusion criteria were obviously and well described, including case definition.

The outcomes used: Changes of body temperature, Sequential Organ Failure Assessment (SOFA) score, PAO2/FIO2, viral load, serum antibody titer, routine blood biochemical index, ARDS, and ventilatory and (ECMO) support are valid and represent the efficacy of the intervention (Convalescent Plasma ) which is clearly described.

The conclusion of the study is adequate, but the sample size is five which is very low and makes the study underpowered.

Source

    © 2020 the Reviewer (CC BY 4.0).

References

    Chenguang, S., Zhaoqin, W., Fang, Z., Yang, Y., Jinxiu, L., Jing, Y., Fuxiang, W., Delin, L., Minghui, Y., Li, X., Jinli, W., Haixia, X., Yan, Y., Jiuxin, Q., Ling, Q., Li, C., Zhixiang, X., Ling, P., Yanjie, L., Haixia, Z., Feng, C., Kun, H., Yujing, J., Dongjing, L., Zheng, Z., Yingxia, L., Lei, L. Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma. JAMA.