The authors successfully addressed all reviewer's comments. The manuscript is significantly improved over the initial submission and there are no further major concerns. There are only a few minor changes that would improve the fluidity of the manuscript.

INTRODUCTION:

1. In page 6, line 35, where the authors wrote “is an animal model that can potentially useful in research” it should read “is an animal model that can be potentially useful in research”.

DISCUSSION

1. In page 20, from line 32 to 34, where it is written “CYP2C19 transgenic mice either stagnate of spontaneously improve phenotypic characteristics…” it should be “CYP2C19 transgenic mice either stagnate or spontaneously improve phenotypic characteristics…”