Review of A boy with a novel homozygous <i>ZAP70</i> mutation presenting with a dermatological phenotype and postnatal decrease in CD8<SUP>+</SUP> T cells

Content of review 1, reviewed on February 02, 2022

Babayeva et al. reported an interesting case of ZAP-70 deficiency with subtle clinical findings despite abolished ZAP-70 protein expression and progressive reduction in CD8 + T cell counts. The manuscript is well written and the findings are clearly expressed in the study.
- Although as ethnicity is a relevant indicator in the suspected patients, the patient’s ethnical information needs to be clarified.
- Decreased phytohemagglutinin (PHA) response is anticipated in patients with ZAP-70 deficiency. Therefore, providing data regarding PHA could improve the quality.

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Royala, B., Cedric, M., Serhat, K. I., Murat, C., Sevgi, B. E., Cihangir, C. M., Alper, B., Yasemin, K. D., Metin, E., Elif, K., Ahmet, O., S., Z. V., Naomi, T., Safa, B. 2022. A boy with a novel homozygous ZAP70 mutation presenting with a dermatological phenotype and postnatal decrease in CD8+ T cells. Pediatric Allergy and Immunology.

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A boy with a novel homozygous ZAP70 mutation presenting with a dermatological phenotype and postnatal decrease in CD8⁺ T cells

Reviewed On February 02, 2022

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Content of review 1, reviewed on February 02, 2022

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