Content of review 1, reviewed on July 05, 2022
This manuscript has many deficiencies as follows;
1. The sample size is low and the authors have stated this in the discussion as a weakness.
2. If over 40 % of lesions are treatment related how can the oral lesions be predictive of severe disease? This is a typical chicken and egg situation. Which comes first?
3. The authors assume that all patients are infected with the Omicron variant of SASR-COV-2 but they say in the conclusion that the the findings are definitely from a cohort with s single sub-strain infected patient group
Due to these caveats I am uncertain whether oral lesions could be productive of severity of illness.The authors should do a prospective time series study to confirm their hypothesis.
(There are several typos and grammatical errors in the script as well.)
Fo the above reasons I am reluctant to suggest acceptance of the manuscript.
Source
© 2022 the Reviewer.
Content of review 2, reviewed on November 17, 2022
This is a reasonable prospective study of oral lesions in COVID-9 patients and adds to the literature. But there is a major flaw as mentioned below which permeates the whole ms. This should be addressed.
1.sars-CoV-2 should be SARS-CoV-2 Please correct throughout.
2. How did the authors assume that the lesions were virus infections without any virology lab evaluations? This is a critical assumption and should be mentioned as a major weakness of the study in the discussion section.
Source
© 2022 the Reviewer.
References
Gianfranco, F., Giuseppe, B., Angela, T., Chiara, C., Gianluigi, N., Fabio, D., Saverio, C., Francesca, S., Nicola, B., Mario, R., Concetta, V. M., Alberto, C., Elisiana, C., Antonio, M., Maria, C., Daniela, L., Francesca, C., Ali, Q. M. F., Martino, T. G., Luisa, L. 2024. Relationship between oral lesions and severe SARS-CoV-2 infection in intensive care unit patients. Oral Diseases.
