interesting conclusion mainly The current paper provides strong evidence about the antioxidant properties of Orthosiphon stamineus and its fractions as well as their use as cytoprotective against free radical induced cell death. Antipoptotic effect of this plant is suggested to be through the intervention in Bcl-2-mediated apoptotic pathways. The results obtained support the efficacy of natural phenolics from plant origin in offering protection against oxidative injury and highlight the fact that phenolic-rich foods may provide health and nutritional benefits. On the other hand, epidemiological studies have shown a relationship between high dietary intakes of phenolic-rich foods and reduced risk of cardiovascular disease and cancer whereby, the production and development of many diseases are closely related to oxidative damages caused by free radicals