The aim of Yayan’s1 study was to utilize the erythrocyte sedimentation rate (ESR) as a rapid guide to identify patients with acute coronary syndrome (ACS) or myocardial infarction. ESR is arguably a nonspecific biomarker which is elevated in almost every condition. Prakash et al2 have pointed to conflicting reports in the literature documenting the tendency of patients with periodontitis to develop anemia. Hence, this study was undertaken to assess whether periodontitis can cause an anemic state by evaluating and comparing the red blood cell count and levels of hemoglobin, hematocrit, ESR, serum iron, and serum ferritin between subjects with and without periodontitis, anemia, rheumatoid arthritis, and other hematologic conditions.1 However, this study shows that there is no statistically significant difference between rates of ESR in men and women. The purpose of referring to this reference is that most elderly people suffer from periodontitis and this condition is not negligible given that many older people also suffer for concomitant ischemic heart disease. Inflammation arising within the gastrointestinal tract may be of great importance in the pathogenesis of irritable bowel syndrome,2 regarding this fact that ESR is com- monly used to assess the acute phase response,3 this acute phase response may be nonspecific. Elevated ESR is seen more often in elderly patients than in their younger counterparts3 (imagine an elderly patient with elevated ESR and consider whether ESR would be used as the sole basis for diagnosis of heart pain? Of course not!). ESR elevated concomitantly with C-reactive protein is used to confirm adult-onset Still’s disease.4 In an adult who is a heavy smoker with dyslipidemia, a personal history of Still’s disease, and a family history of ischemic heart disease, would you consider Still’s disease or ACS first? Let us suppose a febrile, middle-aged woman is referred with angina pectoris. She has a positive history of anemia, and is suffering from rheumatoid arthritis. Rheumatoid arthritis is generally associated with mild anemia, which is usually normocytic normochromic. Erythropoietin levels are above normal in this patient to compensate for her anemia, hence the normal relationship between EPO in this patient is not associated with the degree of anemia.6 Now how can the clinical presentation be judged solely upon basis of ESR, when the fact that CRP and troponin levels may be helpful in management decision of such patients, as the ESR is falsely elevated in response to increased EPO production?6 C-reactive protein and troponin levels may be helpful in deciding on the management of such patients, because the ESR is falsely elevated in response to increased erythropoietin production. Another case is the diabetic patient with an infected diabetic foot, mild dyspepsia, and heart burn. In a study reported by Lavery et al,7 diabetics were shown to have a significantly higher mean white cell count and ESR than nondiabetic patients (62.3% versus 13.7%, respectively, P , 0.0001). Lavery et al concluded that “while a glaringly elevated WBC count or ESR should alert the clinician to the possibility of infection, normal values should not be relied upon to rule out a serious event.”7 The question arises as to how these patients should be evaluated, given that all of them have electrocardiographic evidence of ischemic heart disease, and the clinical pre- sentation of coronary artery disease (CAD) or ACS varies between diabetics and nondiabetics. Leukocytosis should not be disregarded in the febrile patient with a diabetic foot and according to the article this condition may worsen CAD.7 It is proposed that leukocytosis is an independent and prognostic indicator of cardiovascular disease. But how does the doctor know that the elevated ESR is due to ACS and not related to other conditions (ie independent factors and prognostic indicator of CAD, ACS, and outcome), and how can one be certain that the elevated ESR is related to ACS or CAD, or if it is related to infection or other conditions associated with elevated ESR? Because most patients with CAD are in the older age groups, their basal metabolic rate is decreased, so signs of infections may not present as fever or high temperature. It has been reported that granulocytosis may be associated with development of CAD,8 but the question arises as to how long should granulocytes be elevated to be a criterion for CAD. If the case is complicated by dehydration, hypoglycemia, or any kind of stress, can the involvement of CAD or ACS be judged relevant in this condition? Lastly, let us consider the case of a young man suffering from midsternal pain who is a one-pack-year smoker with a history of dyslipidemia. Gastrointestinal involvement is ruled out by endoscopic studies, and ACS is suspected. It is concluded from the paper by Bacci et al9 that ESR, in addition to being a marker ofACS, is also an indicator of dyslipidemia and obesity. Now, how can this marker be used alone to differentiate between ACS and dyslipidemia? In this author’s Vascular Health and Risk Management Publish your work in this journal Vascular Health and Risk Management is an international, peer- reviewed journal of therapeutics and risk management, focusing on concise rapid reporting of clinical studies on the processes involved in the maintenance of vascular health; the monitoring, prevention and treatment of vascular disease and its sequelae; and the involvement of Dovepress opinion, ESR in conjunction with C-reactive protein and tro- ponin could be useful in predicting the outcome of ACS. Finally, Yayan et al showed that ESR was prolonged in patients with CAD who had undergone a percutaneous coro- nary intervention procedure, and suggest that ESR may be a useful additional diagnostic criterion for CAD.1 Arguably, a study should be conducted to check inflammatory biomark- ers in the absence of confounding factors which may be mis- leading about the patient, ie, fever, an altered immune system leading to hypothermia, and underlying medical conditions, such as inflammatory bowel disease, rheumatoid arthritis, or even systemic lupus erythematosus. Clearly, the possibility of malignancy should also be kept in mind, because most patients with CAD are elderly and this type of disease is common in older people. Disclosure The author has no conflict of interest to report.