The manuscript entitled “Immunohistochemical Expression of Tazarotene-induced gene 3 in Oral Squamous Cell Carcinoma” attempted to evaluate, using immunohistochemistry, the expression of TIG3 in normal oral mucosa and Oral Squamous Cell Carcinoma in comparison to normal skin and Skin Squamous Cell Carcinoma. The authors conclude that “loss of TIG3 is an important event in carcinogenesis. TIG3 acts as a regulator of keratinocyte proliferation and terminal differentiation. Therefore, TIG3 could be a potential biomarker to differentiate aggressive and nonaggressive neoplasms.”
The present study analyzed the expression of only one marker involved in suppression of hyperproliferative, in a small number of cases per group.
The methodology of this study is adequate to evaluate the expression of TIG3 in microenvironment of OSCC and SSCC compared to control (normal mucosa and skin), however inappropriate to assess the role of TIG3 in different stages of carcinogenesis. To this end, it would be necessary to evaluate the expression of the TIG3 in potentially malignant lesions.
The discussion should be improved to provide a best explanation and discussion of the results.