The manuscript by Faure et al. describes the C3-functionalization of the cephalosporin pharmacophore. The authors have optimized the Pd-catalysed Suzuki-Miyaura cross-coupling reaction condition and applied it to generate several C3-functionalized cephalosporin derivatives. The derivatives are properly characterized, and side reactions are also investigated. After noting the following points, the manuscript is suitable for publication in the New Journal of Chemistry.
• For the derivatives 3b-g, MIC values may be reported to check the antibacterial activity (Escherichia coli and Staphylococcus aureus)