The authors present their effort to integrate the command line NCBI BLAST+ tool suite into the Galaxy platform, providing a full set of wrappers, BLAST related tools and datatype definitions.

The manuscript is clearly written and includes several useful use-cases and workflows combining the tools within Galaxy. The tools are not available through a public server for testing, but the authors crafted an excellent virtual machine providing a complete Galaxy server with the BLAST+ tools preinstalled.

In my opinion the work represents a valuable addition to the software resources available to the Galaxy community, hence my recommendation to its publication. Level of interest An article of importance in its field Quality of written English Acceptable Statistical review No, the manuscript does not need to be seen by a statistician. Declaration of competing interests One of the authors has been a colleague of mine. I have no competing interests.

Authors' response to reviewers: (http://www.gigasciencejournal.com/imedia/2914911191674395_comment.pdf)