Comment on Abstract: The sentence of (trials on tumor cell lines were conducted, which identified challenges

arising from measurements in biological material) need to be revised or (removed) as explained in section 3.3 there is no result presented and the idea fails.

Comments on introduction: The introduction is good and well explained.

comments on the results: Figure 4 and Figure 5 are similar why is repeated and Figure 4 is the CVP test for nanoparticles not ionic species, please revised.

Figure 6, why the signal amplitude is different?