The study covers the epidemiology and genetic findings of the Livestock-Associated MRSA (LA-MRSA) across the UK. All MRSA strains - LA-MRSA, Hospitalar-Associated MRSA (HA-MRSA) and Community-associated MRSA (CA-MRSA) - are particularly relevant as a Multi-Resistant Organism (MRO). They can be carried widely in a diversity of environments (Hospital, community and animal-bound) and has the potential of challenging infection in humans.

  The contribution of LA-MRSA to the epidemiology of MRSA-associated infections is still not entirely clear. Measures of detection and control are of importance. Yet Europe (and the world) does not appear to have standardised those to this date.

  The study offers a relevant contribution to pubic epidemiology authorities and healthcare professionals as it attempts to evaluate the question; it focuses on data about LA-MRSA, rather than mention the remaining strains.

Strengths of the study

1. A relevant theme, well delimited in methodology.
2. Adequate mention of the burden of LA-MRSA and current epidemiology of LA-MRSA throughout Europe and specifically the UK
3 The study presents an extensive, concise, thorough and relevant revision of many aspects of the theme: screening collection and detection methods; animal, human and environment colonisation; Antimicrobial resistance/epidemiology; eradication, human pathogenicity, occupational risk.

Major weakness

1. Since it is a review, the authors should have established the criteria for inclusion and exclusion of studies (risk of bias).
2. The authors did not reach the promised objection, as the conclusion lacks specific recommendations

Minor weaknesses

1. The Abstract omits the conclusions or mentions of those.
2. The authors should illustrate the chronology and details of detection of LA-MRSA throughout the UK.
3. Facts to be explored include accidental X surveillance; methodology of detection; genome/strains, across the years.
4. The authors could have documented those through a graphic time-line for better understanding. A growing trend in the detection, and the predominance of some specific strain, would represent indirect evidence for future measures.
5. The authors could have documented the phylogenetics of LA-MRSA through an in an infographic for clarity.
6. The study does not state enough ground to define the best methods or needs for surveillance of healthy livestock  (Discussion, paragraphs 1 and 2)
7. The study does not offer strong enough evidence for the suggestions of systematic and structure surveillance (Discussions paragraph 4-5).