Content of review 1, reviewed on November 17, 2020

1 Experimental work is highly commended.
2. The conclusion is not based on this study. Should modify/rewrite the conclusion
3. Fold change observed is shisha exposed cells are low (S Tables 1&2) . Is there a threshold you can use, below which the result is insignificant? If you take a two-fold difference as the threshold only one gene is differentially expressed in Table 1. Please clarify this.
4.What are the limitations of your study? Please add a paragraph.

Source

    © 2020 the Reviewer.

Content of review 2, reviewed on December 10, 2020

Experimental work is highly commended. Thank you for making the revisions. You have missed the opportunity to explain the translational value of your research adequately to the reader.

Source

    © 2020 the Reviewer.

References

    Niraj, B., Shankargouda, P., V., M. S., Tejaswini, S., Jayshree, A., K., D. K., Pavithra, R., Ahmad, B. F., David, S., Harsha, G., Aditi, C. 2021. Signaling alterations in oral keratinocytes in response to shisha and crude tobacco extract. Journal of Oral Pathology and Medicine.