The authors present an investigation into type 1 g-NEN cohorts, employing a relatively small sample size to unveil a comprehensive proteomic signature through DIA-LC/MS/MS analysis. Their methodology adheres to a well-established routine in the field of proteomics, lending credibility to their findings. The clarity of both results and interpretations is commendable. Despite the limited sample size, which somewhat constrains the broader implications of the research, the manuscript demonstrates publishable quality, albeit with some suggested improvements.

1. Page 10 lacks a description of Figure 1, which is crucial for readers to fully comprehend the findings. It's essential to provide detailed information and observations in the text to supplement the figures.

2. The Discussion section appropriately highlights the limitation of the small sample size, which could impact the robustness of the conclusions drawn in this study. It's recommended to emphasize this limitation in the Abstract as well, ensuring readers grasp the context and scope of the research from the outset.