The study of Pesarico et al. shows that, even a short chronic stress protocol, can induce changes in interneuronal (PV+) plasticity-related molecules (PNN and NCAM) in cortical and extracortical regions. It has been mainly focused on the on the medial prefrontal cortex (mPFC), basolateral amygdala (BLA), hippocampus and also explored the habenula and the thalamic reticular nucleus. The PNNs have been considered promising targets to enhance CNS repair, and the NCAM has been thought to take part in neural plasticity and inducing neurite outgrowth, therefore the article dissects a timely question in relation to stress.