Summary
The authors should also introduce the rationale, why these flours are important?
It is not clear how many samples were tested
Please explain why just JAO was furtherly assessed on cell lines.
These cell lines are not familiar for most of the readers, could you also explain why did you use this and not another….
The authors should end the summary with a little conclusion section. For what the results of this research could be useful?
Introduction
In general the references of this section are a bit old and should be updated
Lines 48-49: …to produce flours that are easily obtained by consumers in the local market. Please revise this sentence in a more fluent form.
Line 52: The diverse chemical composition…please specify of what
Lines 52-55: The diverse chemical….jatobá pulp. Please revise this sentence, because it sounds confused.
Line 57: antioxidant properties. Just some lines before you stated that this features were already studied. Please revise, because it is not clear.
Line 67 the long term…Long Term COVID-19
Line 68: opportunistic pathogens…opportunistics or pathogens
Line 69: Enterococcus genus is not including pathogens or opportunistics. The case of bacteriemia are extreme conditions not to define pathogens.

Line 68: An increase…please change in Increases
Line 69 low proportions…please change in reductions
Line 82: Here…please use in the present work or something similar
Lines 83 – 88: In particular, we used…metabolic profile. Please revise this sentence, because is too long and confused.
Line 84: in vitro continuous…
Materials
Please specify all other reagents or omit this section and specify the suppliers in the text.
Line 98: Fisher Scientific (Loughborough, UK). Is the detail’s supplier correct?
Line 104: where in Miranda?
Line 120: Covid-19 and were fully recovered at the point of the donation. Could you please indicate approximately how much time passed from recovery to donation?
Line 121: The samples were…plastic bag. Please revise this part, was any O2 catalyst included?
Line 122: Where, how and for how long did you stored the donations?
Line 121 -123: On the day of the…(PBS, pH 7.4). This part should be described better. Keeping the anaerobic condition is essential to resemble in vivo conditions.
Line 141: 10 min at 1,300 x g…maybe there’s an error, please check and confirm.
Results
Please italicize the p