1. line 72 to 74, it might be easier for the reader if the citation was placed after the diseases, such as TBI [1], ALS [2]....
2. line 124, it might be important to describe the 3xTG-AD mice (with citation) that these mice contain 3 mutations (MAPT P301L, APP Swedish and PSEN1 M146V).
3. Line 160: I models?
4. line 304. 305: citations?
5. line 351, the citation does not seem correct, it could be citation 112. It might be better to clarify that the DAM phenotype was originally defined in an amyloidogenic mouse AD model.
6. line 352, please double check citation 107, this might be a tauP301L (Tg4510) mouse model, not PS19.
7. line 375: It might be better to tell the reader that TREM2 is upregulated in the substantia nigra of PSP patients.

The authors have adequately addressed the comments in the revised version of the manuscript. Very well written.