The authors have provided a satisfactory point-by-point answer to all the reviewer's comments and have addressed all the reviewer's concerns. The reviewer notes that the additional ThT and leakage experiments nicely support the lipid-chaperone hypothesis, thus improving the manuscript. Further, it is also positive that experiments involving a peptide (IAPP) have been included in this manuscript for a journal dedicated to proteins. The manuscript can therefore now be Accepted for publication.

Minor comment: in Figure 7, it would be less confusing if a blue line is used for 40%chol in BOTH panels A&B; whilst a red line is used for 20%chol in BOTH panels A&B;.