Title: concise, interesting, clear and reflecting the main research finding, however abbreviations in the title should be avoided Abstract: Well written. Ket words: Keep with MeSH, https://meshb.nlm.nih.gov/MeSHonDemand The aim of this paper is clear. The methodology is outlined, shows satisfied validity and reliability, however inclusion and exclusion criteria should be defined clearly in this section. The results and conclusions match with the aim. Figure1 and Figure 2 legends should begin with the disease instead of the stains. Discussion: The authors discussed PD-L1 and STAT3 immunohistochemical markers in Large B cell lymphoma very well, however there are many related genes should not be missed in the discussion like MuM1 to compare the clinical and diagnostic utility. Weaknesses of the study needs to be more specific. References: well cited and well formatted, however reference number 15 should be updated. The conclusion of the study answers the aim of the work and it is supported by references The study gives future research some opportunities to complete and work on it.