Content of review 1, reviewed on April 25, 2017

This article is a case report about the effectiveness of Mohs chemosurgery technique in the patients with local advanced breast cancer. This article is unique and interesting, however some revisions are needed before publicaton.

COMMENTS: 1. Authors should briefly describe the methodology and criteria to assess ER, PR, and HER2 positivity.

  1. Patient 1 had a compression fracture. Was it due to osteoporosis or bone metastasis? PET/CT sometimes fails to detect bone metastasis.

  2. Why was letrozole selected, even though patient 1 had a compression fracture?

  3. Are there any published reports that the effectiveness of Mohs paste differs from tumor phenotype?

  4. To obtain negative surgical margin after Mohs chemotherapy, do the authors have any cautionary advice?

Source

    © 2017 the Reviewer (CC BY 4.0).

References

    Tsukada, T., Nakano, T., Matoba, M., Matsui, D., Sasaki, S. 2012. Locally advanced breast cancer made amenable to radical surgery after a combination of systemic therapy and Mohs paste: two case reports. Journal of Medical Case Reports, 6(1): 360.