Content of review 1, reviewed on January 10, 2023

Dear Authors

This is a well written and analyzed manuscript dealing with how glp-1, oxyntomodulin and PYY may affect our the brain perception and food restrain.

Importantly, the authors compare their findings to post-RYGb, this is very elegant and allow us to better understand the comparable impact of GOP and other hormones after RYGB.

Here are my concerns:

1) it should be more clear that this is a sub-study, in the title, abstrac,t introduction etc.

2) the authors did not find an effect on several parameters but could this be due to power? please provide some calculations on power

3) why is food restrain affected by both treatment/intervention? Is it GLP-1, OXM or PYY?

Source

    © 2023 the Reviewer.

Content of review 2, reviewed on February 12, 2023

No further comments
best Nicolai J. Wewer Albrechtsen

Source

    © 2023 the Reviewer.

References

    Preeshila, B., Haya, A., D., M. A., George, T., Kleopatra, A., M., A. M., Sanjay, P., Krishna, M., R., A. A., R., B. S., M., T. T. 2023. Tripeptide gut hormone infusion does not alter food preferences or sweet taste function in volunteers with obesity and prediabetes/diabetes but promotes restraint eating: A secondary analysis of a randomized single-blind placebo-controlled study. Diabetes, Obesity and Metabolism.