Abstract, Title, and References

1) Abstract is succinct, Aim is clear. Title is informative and relevant

Introduction and Background

2) Addition of headings for Abstract and Background would be worthwhile

3) Is there any published material about the degree of dosage decrease or withdrawal of therapy that could be referenced here?

4) Are there any other studies that give an indication of the degree of myalgia being experienced?

5) The research question is justified, and is clearly outlined

Methods

6) The total number of potential subjects is missing and so is the geographic population from which they were selected

7) The selection process is missing. How were the subjects identified? What methods were used to capture possible subjects?

8) How many subjects were excluded from the initial cohort?

9) The variables are well defined and appear reliable.

Results

10) Tables and figures are relevant and clearly presented

11) Use of tables and text are clear and compliment each other

Discussion and Conclusions

12) There is a difference between the number of combined subjects (73%) and statin alone (59%) that were taking the 40mg dose. This is not mentioned other than in the table.

13) The conclusion does answer the aim of the study, and notes it’s limitations

14) The limitations provide opportunities to inform future research.

15) The results are not overstated and are easily reported

Overall

The study design was appropriate to answer the aim, and added to what is already known on this topic. Selection process could be better defined, and sample size was below the minimum of 30 per group. However the authors note the study’s limitations well, and welcome further research in this area. References are relevant, and layout of report is clear and concise.