The current study aimed to characterize the effects of diet based on whole corn grain on the dynamics of clinical parameters and biochemical metabolites of confined cattle. Twenty young mixed-breed cattle, with a mean weight of 332 kg, were used, divided into two experimental groups. The experimental group (G1; n=15), composed of animals fed only Max Beef Whole Grain diet and the control group (G2; n=5), composed of animals fed with sugarcane bagasse and the Max Beef Grain Whole grain diet, in the ratio 30:70. Blood samples were taken for analysis of different biomarkers of the energy, protein and enzymatic activity. The data were analyzed using the Statistical Analysis System program, and for all analyzes, the 5% probability level was adopted. The cattle in the G1 group showed characteristic clinical manifestations of ruminal acidosis. Inference from the G1 diet on some analyzed variables occurred, highlighted in the energy profile, without putting the animals' health at risk. However, for the use of this type of diet, careful food planning is recommended, especially during the animals' adaptation period.