The authors of "The Role of Membrane Trafficking and the Retromer Complex in Alzheimer's Disease and Parkinson's Disease" put a lot of effort into exploring the involvement of membrane trafficking and the retromer complex in neurodegenerative diseases, which is a critical topic. The manuscript sheds light on the vital role of these processes in cellular function and their potential implications for therapeutic interventions. However, I have identified several areas that require attention before considering the manuscript for publication:

Introduction:
The introduction lacks a clear and focused thesis statement. It would benefit from explicitly stating the main objective of the manuscript, which is to explore the involvement of membrane trafficking and the retromer complex in the onset and progression of Alzheimer's Disease and Parkinson's Disease, as well as their potential as therapeutic targets. Providing a more structured and specific introduction would enhance the overall clarity and coherence of the manuscript.

Physiological Role of Membrane Trafficking and the Retromer Complex:
The section could benefit from a more cohesive structure and more apparent transitions between different aspects of membrane trafficking. The discussion on the recycling, degradation, and retrograde pathways could be better organized, highlighting the specific role of the retromer complex in each pathway. Additionally, providing more specific examples of cargo molecules and their sorting mechanisms would enhance understanding of the topic.

Emerging Pathophysiological Role of the Retromer Complex:
The section could be strengthened by providing more specific evidence from research studies, such as experimental findings or clinical observations, to support the claims. Including relevant studies investigating the effects of retromer dysfunction on disease pathology would add credibility and depth to the discussion.

Conclusion:
The conclusion would benefit from a more comprehensive synthesis of the key findings and their implications. It should emphasize the significance of the discussed mechanisms in understanding AD and PD pathogenesis and provide a more precise direction for future research and therapeutic interventions.

Overall, the manuscript provides a solid overview of the role of membrane trafficking and the retromer complex in AD and PD. However, it would benefit from improvements in the organization of content, clarity of thesis statement and transitions, incorporation of more specific examples and evidence, and a more comprehensive and forward-looking conclusion. Addressing these weaknesses would enhance the manuscript's coherence, readability, and scientific rigor.

Authors have now suffeciently revised the MS as per comments.