Comments on Abstract, title and references

The aim of the study is clear and invites to read. The study found was clear, they did this through a clinical trial on 36 patients with COVID-19. The references were very relevant, very recent, correctly and most appropriate key studies included, Except the reference number 10 needs revision.

Comments on Introduction/background

The introduction is clear in already known about this topic. the research question clearly outlined. The research question relied on some known Chinese clinical trials on this topic.

Comments on Methods

The process of subject selection clear and need further studies. The variables defined and measured appropriately. The study methods valid and reliable. There is enough detail in order to replicate the study.

Comments on data and results

The data is presented in an appropriate way. Tables and figures relevant and clearly presented. Appropriate units, rounding, and number of decimals. Titles, columns, and rows labelled correctly and clearly. Categories grouped appropriately. The text in the results add to the data and it is not repetitive. The statistically significant results are clear. The practically meaningful result is beneficial and clear.

Comments on discussion and conclusions

The results are discussed from multiple angles and placed into context without being overinterpreted. The conclusions answer the aims of the study, but, it was not yet put after discussion section, as it was only included in the abstract. The conclusions are not supported by references or results. The limitations of the study are they opportunities to inform future research.

Structure comments into a full review

Overall statement or summary of the article

The study evaluate the role of hydroxychloroquine and azithromycin on respiratory viral loads., they did this through a clinical trial treatment to hydroxychloroquine and azithromycin on 36 French Confirmed COVID-19 patients. Twenty cases were treated in this study and 16 Untreated patients from another center and cases refusing the protocol were included as negative controls. The results show that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin.

Overall strengths of the article

The general strengths of the article are discussing a global problem, which is the a novel coronavirus (named SARS-CoV-2 latter) and trying to find the appropriate treatment to reduce the risk and spread of the virus.

Specific comments on weaknesses of the article and what could be done to improve it.

Major points in the article which needs clarification, refinement, reanalysis, rewrites and/or additional information and suggestions for what could be done to improve the article.

1. Small sample size, This article needs to increase the number of study population.
2. Try clinical trials of these treatments for different ages, especially for patients who have immune problems and chronic diseases.
3. Clinical trials of these treatments require a longer period of time than mentioned in this study to monitor side effects.
4. The conclusions section is not included in the text. This may depend on the style of the journal.

Minor points like figures/tables not being mentioned in the text, a missing reference, typos, and other inconsistencies. 1. The reference number 10 needs revision.