interesting conclsion that zerumbone from Zingiber zerumbet, exert gastroprotection activity against ethanol- induced gastric ulcer model in rats. The gastroprotective mechanisms of zerumbone may possibly assign to its effect on the enhancement and raising the complementary action of gastric mucosal protective factors, such as the significant increased in the endogenous antioxidant GSH accompanied by the reduction of lipid peroxidation level. Moreover, zerumbone increased NP-SH and PGE 2 contents, those may involved in the resulted increased gastric mucus production. Zerumbone also up-regulated the expression of HSP70 to the gastric mucosal tissue. The study as well established the antisecretory activity of zerumbone compound in the pylorus ligature model, which may augment the observed gastroprotection action. Furthermore, zerumbone showed significant antimicrobial efficacy against H. pylori. Our work affords scientific evidences to the observed gatroprotective activity of zerumbone compound, making it a promising antiulcer compound. However, bearing in mind the presented gastroprotective mechanisms, and even though zerumbone was not tested against other ulcer model, yet, other mechanisms may be implicated and their parts, still need to be elucidated.