Content of review 1, reviewed on March 17, 2024

The paper presents a innocuous (seemingly) interventional, non-controlled study on circadian rhythm simulation lighting among a cohort of schizophrenia patients. While the preliminary findings are promising, suggesting therapeutic potential through circadian rhythm modulation, several clarifications are necessary.

Patient characteristics should be more thoroughly provided. For instance, were individuals undergoing treatment changes excluded during the 10-week intervention period? If not, how will we refine the positive effects of lighting? Additionally, the authors mention the inclusion of "stable" patients, but what are the objective criteria for stability?

It is noted that one patient experienced neuropsychiatric complications due to lighting treatment. I am curious about the specifics of this case, including what occurred and when it occurred.

Evaluation of clinical changes should extend beyond the Brief Psychiatric Rating Scale (BPRS) to include more detailed scales such as the Positive and Negative Syndrome Scale (PANSS). Similarly, the Mini-Mental State Examination (MMSE) may be insufficient for comprehensively assessing cognitive improvement and should be acknowledged as a limitation.

The rationale for the study in the introduction should be strengthened. While circadian rhythm disturbances in schizophrenia are mentioned, there is no discussion on chronotype or its relationship to psychopathology and overall medical condition/morbidity. Relevant literature should be cited to address these gaps (see PMID: 32750762, 34332427 and 34521282). Furthermore, the introduction should briefly outline the outcomes of light interventions in various psychiatric disorders.

A hypothesis should be clearly stated.

The conclusion requires further development. Is light therapy practical for inpatient or outpatient settings? In which patients should it be preferred? Please provide clinically relevant guidance in your recommendations.

Source

    © 2024 the Reviewer.

Content of review 2, reviewed on June 11, 2024

acceptable as is.

Source

    © 2024 the Reviewer.

References

    Ya-Chi, T., Jwo-Huei, J., Ching-Chi, H., Ming-Chang, S., Luke, T., Dipanshu, S. 2024. Circadian lighting effect for inpatients with schizophrenia: A prospective cohort study. Brain and Behavior.